Crosslinking Reagents
Cayman Chemical LognIc AcId 50mg
An acaricide provides 100 control of mites when used at a concentration of 25 ppm a positive allosteric modulator of GABA receptors containing the Rdl subunit homolog TuGABAR in T urticae (spider mites) shifting the GABA-induced response from an EC50 value of 24 8 to 4 83 UM when used at a concentration of 30 UM
Cayman Chemical EZ-LocostatIn 50mg
An inhibitor of MMP-1 MMP-2 and MMP-3 (IC50s 1 3 30 and 150 M respectively) selective for MMP-1 MMP-2 and MMP-3 over the proteases thermolysin urease trypsin a-chymotrypsin plasmin and elastase (4 mM)
Med Vet International Comfor-Trate (Maropitant Citrate) Antiemetic Tablets For Dogs, 16mg, 4 Count
Comfor-trate (maropitant citrate) Tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs.
Cayman Chemical Clobetasol PropIonate 5g
A pan-Akt inhibitor (IC50s 0 08 2 and 2 6 nM for Akt1 -2 and -3 respectively) selective for Akt over a panel of 13 kinases (IC50s 100 nM) but does inhibit PKA PKG1a and PKG1B (IC50s 1 3 0 9 and 4 nM respectively) inhibits tumor growth in an SKOV3 mouse xenograft model at 10 30 and 100 mg/kg
Cayman Chemical VulpInIc AcId 50mg
Contains the intermediary and secondary metabolites of PGE2 PGD2 and PGF2a designed for direct use in LC-MS applications
Cayman Chemical SulfosuccInImIdyl 32 BIot 10mg
An inhibitor of the USP1-UAF complex (IC50 0.544 UM for its deubiquitinase activity) and SARS-CoV-2 PLpro (IC50s 0.56 and 0.091 UM using Z-LRGG-AMC or Ub-AMC respectively as PLpro substrates) reduces the levels of USP1 ID-1 ID-2 and ID-3 in K562 cells at 0.5-10 UM decreases the viability of K562 cells (EC50 1.07 UM) induces apoptosis in K562 cells in a concentration-dependent manner
Cayman Chemical C-ReactIve ProteInhumnre 200ug
A DOT1L inhibitor (IC50 0.11 nM) selective for DOT1L over a panel of additional histone methyltransferases at 5 UM
Cayman Chemical TrIcosnoIc AcId 50mg
An inhibitor of P-gp selectively reverses multidrug resistance mediated by P-gp over MRP1- and BCRP-mediated multidrug resistance resensitizes SKOV3TR and OVCAR-8TR cells to paclitaxel reverses P-gp efflux increasing the intracellular accumulation of P-gp substrates in multidrug resistant SKOV3TR and OVCAR-8TR cells prevents paclitaxel-induced overexpression of MDR1 and P-gp protein level increases in OVCAR-8 cells prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model at 50 mg/kg per day in combination with paclitaxel
Cayman Chemical ArtemIsInIc AcId 50mg
An agonist of RAR isoforms (EC50s 77 35 and 4 nM for RARa RARa and RARY respectively) induces growth arrest of MCF-7 and NB4 cells in vitro a natural metabolite of vitamin A
Cayman Chemical DIhydrolIpoIc AcId 50mg
An isomer of iloprost that inhibits platelet aggregation with an IC 50 value of 65 nM
Cayman Chemical PentacosnoIc AcId 50mg
A potent cell impermeable inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50s 18 and 56 UM respectively as measured by mass spectrometry IC50 60 nM in JMJD3 antibody-based assays)
Cayman Chemical RItalInIc AcId 50mg
A potent cell-permeable mimetic of BH3 domains that avidly binds Bcl-2 Bcl-xL and Bcl-W (Ki death proteins leading to apoptosis
Cayman Chemical EZ-DroloxIfen 50mg
An acylhydrazone antifungal active against C. neoformans in vitro (MIC80 0.06 g/ml) increases survival in mouse models of C. neoformans C. albicans or A. fumigatus infection at 20 mg/kg per day p.o.
Cayman Chemical N-Hydroxysulfosuccinimide so
A topically-active imidazole antifungal compound that has broad spectrum activity in vitro against dermatophytes molds yeasts dimorphic fungi and some Gram-positive bacteria a potent inhibitor of cytochrome P450 aromatase (Ki 68 nM IC50 270 nM)